Combined loss of GLP-1R and Y2R does not alter progression of high-fat diet-induced obesity or response to RYGB surgery in mice

• Main Authors: Brandon B. Boland (Author), Michael B. Mumphrey (Author), Zheng Hao (Author), R. Leigh Townsend (Author), Benji Gill (Author), Stephanie Oldham (Author), Sarah Will (Author), Christopher D. Morrison (Author), Sangho Yu (Author), Heike Münzberg (Author), Christopher J. Rhodes (Author), James L. Trevaskis (Author), Hans-Rudolf Berthoud (Author)
• Format: Book
• Published: Elsevier, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Understanding the mechanisms underlying the remarkable beneficial effects of gastric bypass surgery is important for the development of non-surgical therapies or less invasive surgeries in the fight against obesity and metabolic disease. Although the intestinal L-cell hormones glucagon-li...