Biotin Protein Ligase Is a Target for New Antibacterials

• Prif Awduron: Jiage Feng (Awdur), Ashleigh S. Paparella (Awdur), Grant W. Booker (Awdur), Steven W. Polyak (Awdur), Andrew D. Abell (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2016-07-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

There is a desperate need for novel antibiotic classes to combat the rise of drug resistant pathogenic bacteria, such as Staphylococcus aureus. Inhibitors of the essential metabolic enzyme biotin protein ligase (BPL) represent a promising drug target for new antibacterials. Structural and biochemica...