Aptamer-Drug Conjugates of Active Metabolites of Nucleoside Analogs and Cytotoxic Agents Inhibit Pancreatic Tumor Cell Growth

• প্রধান লেখক: Sorah Yoon (লেখক), Kai-Wen Huang (লেখক), Vikash Reebye (লেখক), Duncan Spalding (লেখক), Teresa M. Przytycka (লেখক), Yijie Wang (লেখক), Piotr Swiderski (লেখক), Lin Li (লেখক), Brian Armstrong (লেখক), Isabella Reccia (লেখক), Dimitris Zacharoulis (লেখক), Konstantinos Dimas (লেখক), Tomokazu Kusano (লেখক), John Shively (লেখক), Nagy Habib (লেখক), John J. Rossi (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2017-03-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Aptamer-drug conjugates (ApDCs) have the potential to improve the therapeutic index of traditional chemotherapeutic agents due to their ability to deliver cytotoxic drugs specifically to cancer cells while sparing normal cells. This study reports on the conjugation of cytotoxic drugs to an aptamer p...