Transcriptional Profiling of Human Endothelial Cells Unveils PIEZO1 and Mechanosensitive Gene Regulation by Prooxidant and Inflammatory Inputs

• Үндсэн зохиолчид: German A. Arenas (Зохиогч), Jose G. Valenzuela (Зохиогч), Estefanía Peñaloza (Зохиогч), Adolfo A. Paz (Зохиогч), Rodrigo Iturriaga (Зохиогч), Claudia G. Saez (Зохиогч), Bernardo J. Krause (Зохиогч)
• Формат: Ном
• Хэвлэсэн: MDPI AG, 2023-10-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

PIEZO1 is a mechanosensitive cation channel implicated in shear stress-mediated endothelial-dependent vasorelaxation. Since altered shear stress patterns induce a pro-inflammatory endothelial environment, we analyzed transcriptional profiles of human endothelial cells to determine the effect of alte...