Discovery of coumaric acid derivatives hinted by coastal marine source to seek for uric acid lowering agents

• Autori principali: Yu-Shun Yang (Autore), Bin Wang (Autore), Junzhong Liu (Autore), Qin Li (Autore), Qin-Cai Jiao (Autore), Pei Qin (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

In this work, a series of novel compounds Spartinin C1-C24 were screened, synthesised and evaluated for inhibiting xanthine oxidase thus lowering serum uric acid level. The backbones were derived from the components of coastal marine source Spartina alterniflora and marketed drugs. The top hits Spar...