Integrating IL-12 mRNA nanotechnology with SBRT eliminates T cell exhaustion in preclinical models of pancreatic cancer

• Main Authors: Angela L. Hughson (Author), Gary Hannon (Author), Noah A. Salama (Author), Tara G. Vrooman (Author), Caroline A. Stockwell (Author), Bradley N. Mills (Author), Jesse Garrett-Larsen (Author), Haoming Qiu (Author), Roula Katerji (Author), Lauren Benoodt (Author), Carl J. Johnston (Author), Joseph D. Murphy (Author), Emma Kruger (Author), Jian Ye (Author), Nicholas W. Gavras (Author), David C. Keeley (Author), Shuyang S. Qin (Author), Maggie L. Lesch (Author), Jason B. Muhitch (Author), Tanzy M.T. Love (Author), Laura M. Calvi (Author), Edith M. Lord (Author), Nadia Luheshi (Author), Jim Elyes (Author), David C. Linehan (Author), Scott A. Gerber (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pronounced T cell exhaustion characterizes immunosuppressive tumors, with the tumor microenvironment (TME) employing multiple mechanisms to elicit this suppression. Traditional immunotherapies, such as immune checkpoint blockade, often fail due to their focus primarily on T cells. To overcome this,...