Effect of Poloxamer on release of poorly water soluble drug Loratadine from solid dispersion: Kneading method

• Main Authors: M. Mofizur Rahman (Author), Mohammad Moniruzzaman (Author), Sanjida Haque (Author), M.A.K. Azad (Author), Farjana Islam Aovi (Author), Nazneen Ahmeda Sultana (Author)
• Format: Book
• Published: University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical Association, 2015-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The main objective of the current study was to enhance the solubility and dissolution of poorly water soluble drug Loratadine (LOR) through formulation of solid dispersion systems (SDs) using hydrophilic polymers. SDs were prepared by kneading method using different drug-to-polymer ratios (1:3 and 1...