Changes in urinary output due to concomitant administration of sacubitril/valsartan and atrial natriuretic peptide in patients with heart failure: a multicenter retrospective cohort study

• Main Authors: Tatsuki Yanagawa (Author), Yuki Asai (Author), Nobuyuki Zakoji (Author), Shingo Hosoe (Author), Yoshihiro Kondo (Author), Shinnosuke Ootsuki (Author), Hidekazu Kato (Author), Maria Aoki (Author), Yoshiaki Yamamoto (Author), Takanori Yamamoto (Author), Masaaki Takahashi (Author)
• Format: Book
• Published: BMC, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Sacubitril/valsartan is an angiotensin receptor neprilysin inhibitor (ARNI) that inhibits the degradation of endogenous natriuretic peptides. Therefore, ARNIs may increase the efficacy of human atrial natriuretic peptide (hANP), a drug for acute heart failure, by mediating its ph...