An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer

• Main Authors: Joseph Longo (Author), Peter J. Mullen (Author), Rosemary Yu (Author), Jenna E. van Leeuwen (Author), Mehdi Masoomian (Author), Dixon T.S. Woon (Author), Yuzhuo Wang (Author), Eric X. Chen (Author), Robert J. Hamilton (Author), Joan M. Sweet (Author), Theodorus H. van der Kwast (Author), Neil E. Fleshner (Author), Linda Z. Penn (Author)
• Format: Book
• Published: Elsevier, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The statin family of cholesterol-lowering drugs has been shown to induce tumor-specific apoptosis by inhibiting the rate-limiting enzyme of the mevalonate (MVA) pathway, HMG-CoA reductase (HMGCR). Accumulating evidence suggests that statin use may delay prostate cancer (PCa) progression i...