Suramin Affects the Renal VEGF-A/VEGFR Axis in Short-Term Streptozotocin-Induced Diabetes

• Main Authors: Gabriela Chyła-Danił (Author), Kornelia Sałaga-Zaleska (Author), Ewelina Kreft (Author), Aleksandra Krzesińska (Author), Sylwia Herman (Author), Agnieszka Kuchta (Author), Monika Sakowicz-Burkiewicz (Author), Małgorzata Lenartowicz (Author), Maciej Jankowski (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Diabetic nephropathy (DN) accounts for approximately 50% of end-stage renal diseases. Vascular endothelial growth factor A (VEGF-A) is thought to be a critical mediator of vascular dysfunction in DN, but its role is unclear. The lack of pharmacological tools to modify renal concentrations further hi...