A CTLA-4 Antagonizing DNA Aptamer with Antitumor Effect

• Main Authors: Bo-Tsang Huang (Author), Wei-Yun Lai (Author), Yi-Chung Chang (Author), Jen-Wei Wang (Author), Shauh-Der Yeh (Author), Emily Pei-Ying Lin (Author), Pan-Chyr Yang (Author)
• Format: Book
• Published: Elsevier, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The successful translation of cytotoxic T lymphocyte antigen-4 (CTLA-4) blockade has revolutionized the concept of cancer immunotherapy. Although monoclonal antibody therapeutics remain the mainstream in clinical practice, aptamers are synthetic oligonucleotides that encompass antibody-mimicking fun...