Simvastatin Sensitizes Radioresistant Prostate Cancer Cells by Compromising DNA Double-Strand Break Repair

• Main Authors: Yu-An Chen (Author), Hua-Wei Shih (Author), Yi-Chun Lin (Author), Hui-Ying Hsu (Author), Tsu-Fang Wu (Author), Chen-Han Tsai (Author), Chia-Lin Wu (Author), Hui-Yu Wu (Author), Jer-Tsong Hsieh (Author), Chih-Hsin Tang (Author), Chih-Ho Lai (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Prostate cancer (PCa) is one of the most prevalent male cancers in western world. Radiation therapy (RT) is commonly used to treat PCa patients. However, a certain proportion of patients develop radioresistant PCa cells, which results in metastatic disease. Statins, which inhibit 3-hydroxy-3-methyl...