Sirt3 Exerts Its Tumor-Suppressive Role by Increasing p53 and Attenuating Response to Estrogen in MCF-7 Cells

• Main Authors: Marija Pinterić (Author), Iva I. Podgorski (Author), Marijana Popović Hadžija (Author), Vedrana Filić (Author), Mladen Paradžik (Author), Bastien Lucien Jean Proust (Author), Ana Dekanić (Author), Ivan Ciganek (Author), Denis Pleše (Author), Dora Marčinko (Author), Tihomir Balog (Author), Sandra Sobočanec (Author)
• Format: Book
• Published: MDPI AG, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Estrogen (E2) is a major risk factor for the initiation and progression of malignancy in estrogen receptor (ER) positive breast cancers, whereas sirtuin 3 (Sirt3), a major mitochondrial NAD⁺-dependent deacetylase, has the inhibitory effect on the tumorigenic properties of ER p...