Targeted Delivery of C/EBPα-saRNA by RNA Aptamers Shows Anti-tumor Effects in a Mouse Model of Advanced PDAC

• Main Authors: Sorah Yoon (Author), Kai-Wen Huang (Author), Pinelopi Andrikakou (Author), Daniel Vasconcelos (Author), Piotr Swiderski (Author), Vikash Reebye (Author), Mikael Sodergren (Author), Nagy Habib (Author), John J. Rossi (Author)
• Format: Book
• Published: Elsevier, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies; it preferentially metastasizes to the liver and is the main cause of death from this disease. In previous studies, small activating RNA against CCAAT/enhancer-binding protein-α (C/EBPα-saRNA) demonstrated efficacy of...