Population and Noncompartmental Pharmacokinetics of Sodium Oxybate Support Weight‐Based Dosing in Children and Adolescents With Narcolepsy With Cataplexy

• Main Authors: Cuiping Chen (Author), Carol L. Rosen (Author), Chad Ruoff (Author), Leslie H. Boyce (Author), Rupa Parvataneni (Author), Katie Zomorodi (Author), Scott Brantley (Author), Mark Sale (Author), Giuseppe Plazzi (Author)
• Format: Book
• Published: Wiley, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pharmacokinetics (PKs) of sodium oxybate (SXB) was evaluated in a subset of participants from a study of SXB treatment in children (aged 7-11 years; n = 11) and adolescents (aged 12-17 years; n = 18) with narcolepsy with cataplexy. PK evaluation was conducted over 2 nights during the period when...