High SMAD7 and p-SMAD2,3 expression is associated with environmental enteropathy in children.

• Main Authors: Sana Syed (Author), Vincenzo Dinallo (Author), Najeeha T Iqbal (Author), Laura Di Iorio (Author), Davide Di Fusco (Author), Shan Guleria (Author), Beatrice C Amadi (Author), Kamran Sadiq (Author), Christopher Moskaluk (Author), S Asad Ali (Author), Paul Kelly (Author), Giovanni Monteleone (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Enteropathies such as Crohn's disease are associated with enteric inflammation characterized by impaired TGF-β signaling, decreased expression of phosphorylated (p)-SMAD2,3 and increased expression of SMAD7 (an inhibitor of SMAD3 phosphorylation). Environmental enteropathy (EE) is an acquired i...