Endoplasmic Reticulum Stress in Colonic Mucosa of Ulcerative Colitis Patients Is Mediated by PERK and IRE1 Pathway Activation

Endoplasmic Reticulum Stress in Colonic Mucosa of Ulcerative Colitis Patients Is Mediated by PERK and IRE1 Pathway Activation

Ulcerative colitis (UC) is characterized by a chronic overproduction of proinflammatory cytokines. During an acute phase, the endoplasmic reticulum (ER) is overloaded and the protein folding process is impaired, a condition named ER stress. This state induces a response (unfolded protein response (U...

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Main Authors: Bruno Lima Rodrigues (Author), Isabella Dotti (Author), Lívia Bitencourt Pascoal (Author), Joseane Morari (Author), Miriam Esteller (Author), Andressa Coope (Author), Maria de Lourdes Setsuko Ayrizono (Author), Azucena Salas (Author), Raquel Franco Leal (Author)
Format: Book
Published: Hindawi Limited, 2022-01-01T00:00:00Z.
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