Urolithin A Attenuates Hyperuricemic Nephropathy in Fructose-Fed Mice by Impairing STING-NLRP3 Axis-Mediated Inflammatory Response via Restoration of Parkin-Dependent Mitophagy

• Hlavní autoři: Cong Zhang (Autor), Yingying Song (Autor), Liang Chen (Autor), Peng Chen (Autor), Ming Yuan (Autor), Yan Meng (Autor), Qi Wang (Autor), Guohua Zheng (Autor), Zhenpeng Qiu (Autor)
• Médium: Kniha
• Vydáno: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Urolithin A (UroA) is one of the primary intestinal metabolites of ellagitannins, showing translational potential as a nutritional intervention in humans. Mounting evidence suggests that fructose consumption contributes to the progression of chronic kidney disease (CKD) that manifests in hyperuricem...