NAG-1/GDF15 Transgenic Mouse Has Less White Adipose Tissue and a Reduced Inflammatory Response

• Main Authors: J. M. Kim (Author), J. P. Kosak (Author), J. K. Kim (Author), G. Kissling (Author), D. R. Germolec (Author), D. C. Zeldin (Author), J. A. Bradbury (Author), S. J. Baek (Author), T. E. Eling (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

NAG-1/GDF15 is a TGF-β superfamily member with poorly characterized biological activity proposed to inhibit inflammatory cytokine production. Transgenic mice expressing human NAG-1/GDF15 (NAG-1Tg/Lox) are leaner with lower body weight and are resistant to chemically or genetically induced intestinal...