Mineralocorticoid receptor stimulation induces urinary storage dysfunction via upregulation of epithelial sodium channel expression in the rat urinary bladder epithelium

• Main Authors: Seiji Yamamoto (Author), Yuji Hotta (Author), Kotomi Maeda (Author), Tomoya Kataoka (Author), Yasuhiro Maeda (Author), Takashi Hamakawa (Author), Shoichi Sasaki (Author), Takahiro Yasui (Author), Kiyofumi Asai (Author), Kazunori Kimura (Author)
• Format: Book
• Published: Elsevier, 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We aimed to evaluate mineralocorticoid receptor (MR) expression in rat bladder and the physiological role of the MR-epithelial sodium channel (ENaC) pathway in controlling bladder function in 10-12-week-old, male Sprague-Dawley rats. First, we examined the mRNA expression of MR and localization of M...