Clinical translation of patient-derived tumour organoids- bottlenecks and strategies

• Main Authors: Malia Alexandra Foo (Author), Mingliang You (Author), Shing Leng Chan (Author), Gautam Sethi (Author), Glenn K. Bonney (Author), Wei-Peng Yong (Author), Edward Kai-Hua Chow (Author), Eliza Li Shan Fong (Author), Lingzhi Wang (Author), Boon-Cher Goh (Author)
• Format: Book
• Published: BMC, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Multiple three-dimensional (3D) tumour organoid models assisted by multi-omics and Artificial Intelligence (AI) have contributed greatly to preclinical drug development and precision medicine. The intrinsic ability to maintain genetic and phenotypic heterogeneity of tumours allows for the r...