Genetic or siRNA inhibition of MBD2 attenuates the UUO- and I/R-induced renal fibrosis via downregulation of EGR1

• Main Authors: Kai Ai (Author), Xiaozhou Li (Author), Pan Zhang (Author), Jian Pan (Author), Huiling Li (Author), Zhibiao He (Author), Hongliang Zhang (Author), Lei Yi (Author), Ye Kang (Author), Yinhuai Wang (Author), Junxiang Chen (Author), Yijian Li (Author), Xudong Xiang (Author), Xiangping Chai (Author), Dongshan Zhang (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

DNA methylation plays a pivotal role in the progression of renal fibrosis. Methyl-CpG-binding domain protein 2 (MBD2), a protein reader of methylation, is involved in the development of acute kidney injury (AKI) caused by vancomycin. However, the role and mechanism of action of MBD2 in renal remain...