The Pathogenic Mechanisms of and Novel Therapies for Lamin A/C-Related Dilated Cardiomyopathy Based on Patient-Specific Pluripotent Stem Cell Platforms and Animal Models

• Main Authors: Xin-Yi Wu (Author), Yee-Ki Lee (Author), Yee-Man Lau (Author), Ka-Wing Au (Author), Yiu-Lam Tse (Author), Kwong-Man Ng (Author), Chun-Ka Wong (Author), Hung-Fat Tse (Author)
• Format: Book
• Published: MDPI AG, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Variants (pathogenic) of the <i>LMNA</i> gene are a common cause of familial dilated cardiomyopathy (DCM), which is characterised by early-onset atrioventricular (AV) block, atrial fibrillation and ventricular tachyarrhythmias (VTs), and progressive heart failure. The unstable internal n...