Sickle Cell Disease in Children and Adolescents: A Review of the Historical, Clinical, and Public Health Perspective of Sub-Saharan Africa and Beyond

• Main Authors: Walufu Ivan Egesa (Author), Gloria Nakalema (Author), William M. Waibi (Author), Munanura Turyasiima (Author), Emmanuel Amuje (Author), Gloria Kiconco (Author), Simon Odoch (Author), Patrick Kumbowi Kumbakulu (Author), Said Abdirashid (Author), Daniel Asiimwe (Author)
• Format: Book
• Published: Hindawi Limited, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sickle cell disease (SCD) is an umbrella term for a group of life-long debilitating autosomal recessive disorders that are caused by a single-point mutation (Glu→Val) that results in polymerization of hemoglobin (Hb) and reversible sickle-shape deformation of erythrocytes. This leads to increased he...