Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance

• Main Authors: Nathalia R.V. Dragano (Author), Edward Milbank (Author), Roberta Haddad-Tóvolli (Author), Pablo Garrido-Gil (Author), Eva Nóvoa (Author), Marcos F. Fondevilla (Author), Valentina Capelli (Author), Ariane Maria Zanesco (Author), Carina Solon (Author), Joseane Morari (Author), Leticia Pires (Author), Ánxela Estevez-Salguero (Author), Daniel Beiroa (Author), Ismael González-García (Author), Olga Barca-Mayo (Author), Carlos Diéguez (Author), Ruben Nogueiras (Author), José L. Labandeira-García (Author), Elisabeth Rexen Ulven (Author), Trond Ulven (Author), Marc Claret (Author), Licio A. Velloso (Author), Miguel López (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Free fatty acid receptor-1 (FFAR1) is a medium- and long-chain fatty acid sensing G protein-coupled receptor that is highly expressed in the hypothalamus. Here, we investigated the central role of FFAR1 on energy balance. Methods: Central FFAR1 agonism and virogenic knockdown were perform...