Expression analysis elucidates the roles of Nicastrin, Notch4, and Hes1 in prognosis and endocrine-therapy resistance in ER-positive breast cancer patients

• Main Authors: Arad Boustan (Author), Rosa Jahangiri (Author), Asefeh Dahmardeh Ghalehno (Author), Mahdieh Khorsandi (Author), Fatemeh Mosaffa (Author), Khadijeh Jamialahmadi (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and purpose: Although some proposed mechanisms responsible for tamoxifen resistance have already been present, further study is needed to determine the mechanisms underlying tamoxifen resistance more clearly. The critical role of Notch signaling has been described in promoting resistance...