Cutaneous graft-versus-host disease after hematopoietic stem cell transplant - a review

Abstract Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplants (allo-HSCT) associated with significant morbidity and mortality. The earliest and most common manifestation is cutaneous graft-versus-host disease. This review focuses on the pathophys...

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Main Authors: Cesar Daniel Villarreal Villarreal (Author), Julio Cesar Salas Alanis (Author), Jose Carlos Jaime Pérez (Author), Jorge Ocampo Candiani (Author)
Format: Book
Published: Sociedade Brasileira de Dermatologia, 2016-06-01T00:00:00Z.
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Summary:Abstract Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplants (allo-HSCT) associated with significant morbidity and mortality. The earliest and most common manifestation is cutaneous graft-versus-host disease. This review focuses on the pathophysiology, clinical features, prevention and treatment of cutaneous graft-versus-host disease. We discuss various insights into the disease's mechanisms and the different treatments for acute and chronic skin graft-versus-host disease.
Item Description:0365-0596
10.1590/abd1806-4841.20164180