In vitro intestinal permeability studies, pharmacokinetics and tissue distribution of 6-methylcoumarin after oral and intraperitoneal administration in Wistar rats

• المؤلفون الرئيسيون: Paola Andrea Cárdenas (مؤلف), Jadel Müller Kratz (مؤلف), Aura Hernández (مؤلف), Geison Modesti Costa (مؤلف), Luis Fernando Ospina (مؤلف), Yolima Baena (مؤلف), Cláudia Maria Oliveira Simões (مؤلف), Álvaro Jimenez-Kairuz (مؤلف), Marcela Aragon (مؤلف)
• التنسيق: كتاب
• منشور في: Universidade de São Paulo, 2017-04-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

ABSTRACT 6-Methylcoumarin (6MC) is a semisynthetic coumarin with important in vitro and in vivo anti-inflammatory activity. In order to continue the pre-clinical characterization of this molecule, in vitro intestinal permeability, plasma profile and tissue distribution after oral administration in r...