Randomized evaluation of the loss‐of‐function carboxylesterase 1 (CES1) G143E variant on clopidogrel and ticagrelor pharmacodynamics

• Main Authors: Joshua P. Lewis (Author), Kathleen A. Ryan (Author), Elizabeth A. Streeten (Author), Hilary B. Whitlatch (Author), Melanie Daue (Author), Keith Tanner (Author), James A. Perry (Author), Jeffrey R. O'Connell (Author), Alan R. Shuldiner (Author), Braxton D. Mitchell (Author)
• Format: Book
• Published: Wiley, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Antiplatelet therapy with a P2Y12 receptor inhibitor, in combination with aspirin, is standard of care for medical management of patients with coronary artery disease, and flexibility in prescribing options among these medications offers great potential for individualizing patient care. Pre...