Inhalative IL-10 Attenuates Pulmonary Inflammation following Hemorrhagic Shock without Major Alterations of the Systemic Inflammatory Response

• Main Authors: Philipp Kobbe (Author), Philipp Lichte (Author), Helen Schreiber (Author), Lucy Kathleen Reiss (Author), Stefan Uhlig (Author), Hans-Christoph Pape (Author), Roman Pfeifer (Author)
• Format: Book
• Published: Hindawi Limited, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Several studies report immunomodulatory effects of endogenous IL-10 after trauma. The present study investigates the effect of inhalative IL-10 administration on systemic and pulmonary inflammation in hemorrhagic shock. Male C57/BL6 mice (8 animals per group) were subjected to pressure-controlled he...