IL-1β Suppresses the Formation of Osteoclasts by Increasing OPG Production via an Autocrine Mechanism Involving Celecoxib-Related Prostaglandins in Chondrocytes

• প্রধান লেখক: Yusuke Watanabe (লেখক), Aki Namba (লেখক), Yukiko Aida (লেখক), Kazuhiro Honda (লেখক), Hideki Tanaka (লেখক), Naoto Suzuki (লেখক), Hideo Matsumura (লেখক), Masao Maeno (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Hindawi Limited, 2009-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Elevated interleukin (IL)-1 concentrations in synovial fluid have been implicated in joint bone and cartilage destruction. Previously, we showed that IL-1β stimulated the expression of prostaglandin (PG) receptor EP4 via increased PGE2 production. However, the effect of IL-1β on osteoclast formation...