Lamivudine and Emtricitabine Dosing Proposal for Children with HIV and Chronic Kidney Disease, Supported by Physiologically Based Pharmacokinetic Modelling

• Main Authors: Tom G. Jacobs (Author), Marika A. de Hoop-Sommen (Author), Thomas Nieuwenstein (Author), Joyce E. M. van der Heijden (Author), Saskia N. de Wildt (Author), David M. Burger (Author), Angela Colbers (Author), Jolien J. M. Freriksen (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dose recommendations for lamivudine or emtricitabine in children with HIV and chronic kidney disease (CKD) are absent or not supported by clinical data. Physiologically based pharmacokinetic (PBPK) models have the potential to facilitate dose selection for these drugs in this population. Existing la...