Investigating the role of dystrophin isoform deficiency in motor function in Duchenne muscular dystrophy

• Main Authors: Mary Chesshyre (Author), Deborah Ridout (Author), Yasumasa Hashimoto (Author), Yoko Ookubo (Author), Silvia Torelli (Author), Kate Maresh (Author), Valeria Ricotti (Author), Lianne Abbott (Author), Vandana Ayyar Gupta (Author), Marion Main (Author), Giulia Ferrari (Author), Anna Kowala (Author), Yung‐Yao Lin (Author), Francesco Saverio Tedesco (Author), Mariacristina Scoto (Author), Giovanni Baranello (Author), Adnan Manzur (Author), Yoshitsugu Aoki (Author), Francesco Muntoni (Author)
• Format: Book
• Published: Wiley, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Duchenne muscular dystrophy (DMD) is caused by DMD mutations leading to dystrophin loss. Full‐length Dp427 is the primary dystrophin isoform expressed in muscle and is also expressed in the central nervous system (CNS). Two shorter isoforms, Dp140 and Dp71, are highly expressed i...