Identification of novel PHGDH inhibitors based on computational investigation: an all-in-one combination strategy to develop potential anti-cancer candidates

• Главные авторы: Yujing Xu (Автор), Zhe Yang (Автор), Jinrong Yang (Автор), Chunchun Gan (Автор), Nan Qin (Автор), Xiaopeng Wei (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Предметы: article
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ObjectiveBiological studies have elucidated that phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the serine synthesis pathway in humans that is abnormally expressed in numerous cancers. Inhibition of the PHGDH activity is thought to be an attractive approach for novel anti-canc...