Pro-cancerogenic effects of spontaneous and drug-induced senescence of ovarian cancer cells in vitro and in vivo: a comparative analysis

• Main Authors: Szymon Rutecki (Author), Paulina Szulc (Author), Martyna Pakuła (Author), Paweł Uruski (Author), Artur Radziemski (Author), Eryk Naumowicz (Author), Rafał Moszyński (Author), Andrzej Tykarski (Author), Justyna Mikuła-Pietrasik (Author), Krzysztof Książek (Author)
• Format: Book
• Published: BMC, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Clinical outcomes of cancer cell senescence are still elusive. Here, we reveal and compare pro-cancerous activity of spontaneously and drug-inducible senescent ovarian cancer cells. Experiments were performed on tumors and tumor-derived primary epithelial ovarian cancer cells (pE...