Cryptosporidium Priming Is More Effective than Vaccine for Protection against Cryptosporidiosis in a Murine Protein Malnutrition Model.

• Main Authors: Luther A Bartelt (Author), David T Bolick (Author), Glynis L Kolling (Author), James K Roche (Author), Edna I Zaenker (Author), Ana M Lara (Author), Francisco Jose Noronha (Author), Carrie A Cowardin (Author), John H Moore (Author), Jerrold R Turner (Author), Cirle A Warren (Author), Gregory A Buck (Author), Richard L Guerrant (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cryptosporidium is a major cause of severe diarrhea, especially in malnourished children. Using a murine model of C. parvum oocyst challenge that recapitulates clinical features of severe cryptosporidiosis during malnutrition, we interrogated the effect of protein malnutrition (PM) on primary and se...