Preclinical metabolism and the disposition of vornorexant/TS‐142, a novel dual orexin 1/2 receptor antagonist for the treatment of insomnia

Abstract We investigated the metabolism and disposition of vornorexant, a novel dual orexin receptor antagonist, in rats and dogs, and clarified in vitro metabolite profiles in humans. Furthermore, we investigated the pharmacokinetics of active metabolites in rats and dogs and their CNS distribution...

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Bibliografski detalji
Glavni autori: Yoshihiro Konno (Autor), Shunsuke Kamigaso (Autor), Hidetoh Toki (Autor), Shuichi Terasaka (Autor), Hirohiko Hikichi (Autor), Hiromi Endo (Autor), Jun‐Ichi Yamaguchi (Autor), Akiko Mizuno‐Yasuhira (Autor)
Format: Knjiga
Izdano: Wiley, 2024-04-01T00:00:00Z.
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