Identifying the primary site of pathogenesis in amyotrophic lateral sclerosis - vulnerability of lower motor neurons to proximal excitotoxicity

• Main Authors: Catherine A. Blizzard (Author), Katherine A. Southam (Author), Edgar Dawkins (Author), Katherine E. Lewis (Author), Anna E. King (Author), Jayden A. Clark (Author), Tracey C. Dickson (Author)
• Format: Book
• Published: The Company of Biologists, 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There is a desperate need for targeted therapeutic interventions that slow the progression of amyotrophic lateral sclerosis (ALS). ALS is a disorder with heterogeneous onset, which then leads to common final pathways involving multiple neuronal compartments that span both the central and peripheral...