MGST1 facilitates novel KRASG12D inhibitor resistance in KRASG12D-mutated pancreatic ductal adenocarcinoma by inhibiting ferroptosis

• मुख्य लेखकों: Chungui Xu (लेखक), Weihao Lin (लेखक), Qi Zhang (लेखक), Yarui Ma (लेखक), Xue Wang (लेखक), Ai Guo (लेखक), Guiling Zhu (लेखक), Zhendiao Zhou (लेखक), Weiwei Song (लेखक), Ziyi Zhao (लेखक), Yuchen Jiao (लेखक), Xiaobing Wang (लेखक), Chunxia Du (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2024-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer with a low 5-year survival rate. Treatment options for PDAC patients are limited. Recent studies have shown promising results with MRTX1133, a KRASG12D inhibitor that demonstrated potent antitumor activity in vario...