MGST1 facilitates novel KRASG12D inhibitor resistance in KRASG12D-mutated pancreatic ductal adenocarcinoma by inhibiting ferroptosis

• Main Authors: Chungui Xu (Author), Weihao Lin (Author), Qi Zhang (Author), Yarui Ma (Author), Xue Wang (Author), Ai Guo (Author), Guiling Zhu (Author), Zhendiao Zhou (Author), Weiwei Song (Author), Ziyi Zhao (Author), Yuchen Jiao (Author), Xiaobing Wang (Author), Chunxia Du (Author)
• Format: Book
• Published: BMC, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer with a low 5-year survival rate. Treatment options for PDAC patients are limited. Recent studies have shown promising results with MRTX1133, a KRASG12D inhibitor that demonstrated potent antitumor activity in vario...