New Antifungal Compound: Impact of Cosolvency, Micellization and Complexation on Solubility and Permeability Processes
Poor solubility of new antifungal of 1,2,4-triazole class (S-119)-a structural analogue of fluconazole in aqueous media was estimated. The solubility improvement using different excipients: biopolymers (PEGs, PVP), surfactants (Brij S20, pluronic F-127) and cyclodextrins (α-CD, β-CD, 2-HP-β-CD, 6-O-...
Saved in:
Main Authors: | Tatyana V. Volkova (Author), Olga R. Simonova (Author), German L. Perlovich (Author) |
---|---|
Format: | Book |
Published: |
MDPI AG,
2021-11-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Chiral Recognition R- and RS- of New Antifungal: Complexation/Solubilization/Dissolution Thermodynamics and Permeability Assay
by: Tatyana V. Volkova, et al.
Published: (2022) -
Revisiting the Solubility-Permeability Relationship with Hydrophobic Drug Umifenovir in Pluronic Solutions: Impact of pH and Co-Solvent
by: Tatyana Volkova, et al.
Published: (2023) -
Physicochemical Profile of Antiandrogen Drug Bicalutamide: Solubility, Distribution, Permeability
by: Tatyana V. Volkova, et al.
Published: (2022) -
Cyclodextrin's Effect on Permeability and Partition of Nortriptyline Hydrochloride
by: Tatyana Volkova, et al.
Published: (2023) -
Controlling the Solubility, Release Rate and Permeation of Riluzole with Cyclodextrins
by: Tatyana Volkova, et al.
Published: (2024)