l-Citrulline ameliorates cerebral blood flow during cortical spreading depression in rats: Involvement of nitric oxide- and prostanoids-mediated pathway

• Main Authors: Yuki Kurauchi (Author), Koichi Mokudai (Author), Asami Mori (Author), Kenji Sakamoto (Author), Tsutomu Nakahara (Author), Masahiko Morita (Author), Ayako Kamimura (Author), Kunio Ishii (Author)
• Format: Book
• Published: Elsevier, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

l-Citrulline is a potent precursor of l-arginine, and exerts beneficial effect on cardiovascular system via nitric oxide (NO) production. Migraine is one of the most popular neurovascular disorder, and imbalance of cerebral blood flow (CBF) observed in cortical spreading depression (CSD) contributes...