Effects of Atorvastatin, Amlodipine, and Their Combination on Vascular Dysfunction in Insulin-Resistant Rats

• Main Authors: Tomio Okamura (Author), Masashi Tawa (Author), Ayman Geddawy (Author), Takashi Shimosato (Author), Hirotaka Iwasaki (Author), Haruo Shintaku (Author), Yuichi Yoshida (Author), Masahiro Masada (Author), Kazuya Shinozaki (Author), Takeshi Imamura (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: Deficiency of tetrahydrobiopterin (BH4) in the vascular tissue contributes to endothelial dysfunction through reduced eNOS activity and increased superoxide anion (O2−) generation in the insulin-resistant state. We investigated the effects of atorvastatin, a 3-hydroxyl-3-methylglutaryl co...