Nanoparticle-Mediated Therapy with miR-198 Sensitizes Pancreatic Cancer to Gemcitabine Treatment through Downregulation of VCP-Mediated Autophagy

• Main Authors: Christian Marin-Muller (Author), Dali Li (Author), Jian-Ming Lü (Author), Zhengdong Liang (Author), Osvaldo Vega-Martínez (Author), Sue E. Crawford (Author), Mary K. Estes (Author), William E. Fisher (Author), Changyi Chen (Author), Qizhi Yao (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pancreatic ductal adenocarcinoma (PDAC) remains an extremely aggressive disease characterized by rapidly acquired multi-drug resistance, including to first-line chemotherapeutic agent gemcitabine. Autophagy is a process that is often exploited by cancer and is one of several intrinsic factors associ...