Local Overexpression of Interleukin-11 in the Central Nervous System Limits Demyelination and Enhances Remyelination

• Main Authors: Anurag Maheshwari (Author), Kris Janssens (Author), Jeroen Bogie (Author), Chris Van Den Haute (Author), Tom Struys (Author), Ivo Lambrichts (Author), Veerle Baekelandt (Author), Piet Stinissen (Author), Jerome J. A. Hendriks (Author), Helena Slaets (Author), Niels Hellings (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Demyelination is one of the pathological hallmarks of multiple sclerosis (MS). To date, no therapy is available which directly potentiates endogenous remyelination. Interleukin-11 (IL-11), a member of the gp130 family of cytokines, is upregulated in MS lesions. Systemic IL-11 treatment was shown to...