Novel piperazine-chalcone hybrids and related pyrazoline analogues targeting VEGFR-2 kinase; design, synthesis, molecular docking studies, and anticancer evaluation

• المؤلفون الرئيسيون: Marwa F. Ahmed (مؤلف), Eman Y. Santali (مؤلف), Radwan El-Haggar (مؤلف)
• التنسيق: كتاب
• منشور في: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

New piperazine-chalcone hybrids and related pyrazoline derivatives have been designed and synthesised as potential vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors. The National Cancer Institute (NCI) has selected six compounds to evaluate their antiproliferative activity in vitro...