A new approach to produce [18F]MC225 via one-step synthesis, a PET radiotracer for measuring P-gp function

• Main Authors: Lara Garcia-Varela (Author), Khaled Attia (Author), John Carlo Sembrano (Author), Olivier Jacquet (Author), Inês F. Antunes (Author), Chantal Kwizera (Author), Ton J. Visser (Author), Rudi A. J. O. Dierckx (Author), Philip H. Elsinga (Author), Gert Luurtsema (Author)
• Format: Book
• Published: SpringerOpen, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background [18F]MC225 is a radiotracer for imaging P-glycoprotein (P-gp) function at the blood-brain barrier. The P-gp function can be altered due to different factors, for instance, decreased P-gp function has been described in patients with Alzheimer's or Parkinson's Disease. Th...