Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications

• Main Authors: Alessia Alunno (Author), Mirko Manetti (Author), Sara Caterbi (Author), Lidia Ibba-Manneschi (Author), Onelia Bistoni (Author), Elena Bartoloni (Author), Valentina Valentini (Author), Riccardo Terenzi (Author), Roberto Gerli (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In recent years several studies investigated the role of T lymphocyte subpopulations in the pathogenesis of rheumatoid arthritis (RA). Pathogenic Th17 cells mediate pannus growth, osteoclastogenesis, and synovial neoangiogenesis; hence they are key players in the development of the disease. On the o...