Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH

• Main Authors: Ziqi Huang (Author), Kun Zhang (Author), Yurui Jiang (Author), Mengmeng Wang (Author), Mei Li (Author), Yuda Guo (Author), Ruolin Gao (Author), Ning Li (Author), Chenyang Wang (Author), Jia Chen (Author), Jiefu Wang (Author), Ning Liu (Author), Xiang Liu (Author), Shuangwei Liu (Author), Mingming Wei (Author), Cheng Yang (Author), Guang Yang (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer stem cells (CSCs) play a pivotal role in tumor initiation, proliferation, metastasis, drug resistance, and recurrence. Consequently, targeting CSCs has emerged as a promising avenue for cancer therapy. Recently, 3-phosphoglycerate dehydrogenase (PHGDH) has been identified as being intricately...