Alternative Strategies for Delivering Immunotherapeutics Targeting the PD-1/PD-L1 Immune Checkpoint in Cancer

• Main Authors: Ryunosuke Hoshi (Author), Kristyna A. Gorospe (Author), Hagar I. Labouta (Author), Taha Azad (Author), Warren L. Lee (Author), Kelsie L. Thu (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2024-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) immune checkpoint constitutes an inhibitory pathway best known for its regulation of cluster of differentiation 8 (CD8)⁺ T cell-mediated immune responses. Engagement of PD-L1 with PD-1 expressed on CD8<sup>+&l...