The pungent substances piperine, capsaicin, 6-gingerol and polygodial inhibit the human two-pore domain potassium channels TASK-1, TASK-3 and TRESK

• Главные авторы: Leopoldo Raul Beltran (Автор), Corinna eDawid (Автор), Madeline eBeltran (Автор), Guenter eGisselmann (Автор), Katharina eDegenhardt (Автор), Klaus eMathie (Автор), Thomas eHofmann (Автор), Hanns eHatt (Автор)
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• Опубликовано: Frontiers Media S.A., 2013-11-01T00:00:00Z.
• Предметы: article
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For a long time, the focus of trigeminal chemoperception has rested almost exclusively on TRP channels. However, two-pore domain (K2P) potassium channels have recently been identified as targets for substances associated with typical trigeminal sensations, such as numbing and tingling. In addition,...